PUBLICATIONS
2020
Gray SC, Kinghorn KJ, Woodling NS.
Neural Regen Res. 2020 Jan 15(7):1208-1219. doi: 10.4103/1673-5374.272571
2019
A triple drug combination targeting components of the nutrient-sensing network maximizes longevity.
Castillo-Quan JI, Tain LS, Kinghorn KJ, Li L, Grönke S, Hinze Y, Blackwell TK, Bjedov I, Partridge L.
Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):20817-20819. doi: 10.1073/pnas.1913212116. Epub 2019 Sep 30.
2017
The emerging role of autophagic-lysosomal dysfunction in Gaucher disease and Parkinson's disease.
Kinghorn KJ, Asghari AM, Castillo-Quan JI.
Neural Regen Res. 2017 Mar;12(3):380-384. doi: 10.4103/1673-5374.202934
2016
Kinghorn KJ, Grönke S, Castillo-Quan JI, Woodling NS, Li L, Sirka E, Gegg M, Mills K, Hardy J, Bjedov I, Partridge L.
J Neurosci. 2016 Nov 16;36(46):11654-11670.
Kinghorn KJ, Castillo-Quan JI, Li L, Bhatia KP, Abramov AY, Hardy J, Partridge L.
Brain. 2016 Dec;139(Pt 12):e68. Epub 2016 Aug 6.
Kinghorn KJ, Castillo-Quan JI.
Rare Dis. 2016 Jan 25;4(1):e1128616. doi: 10.1080/21675511.2015.1128616. eCollection 2016.
Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis.
Castillo-Quan JI, Li L, Kinghorn KJ, Ivanov DK, Tain LS, Slack C, Kerr F, Nespital T, Thornton J, Hardy J, Bjedov I, Partridge L.
Cell Rep. 2016 Apr 19;15(3):638-650. doi: 10.1016/j.celrep.2016.03.041. Epub 2016 Apr 7.
2015
Genetics and pharmacology of longevity: the road to therapeutics for healthy aging.
Castillo-Quan JI, Kinghorn KJ, Bjedov I.
Adv Genet. 2015;90:1-101. doi: 10.1016/bs.adgen.2015.06.002. Epub 2015 Jul 29. Review.
Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction.
Kinghorn KJ, Castillo-Quan JI, Bartolome F, Angelova PR, Li L, Pope S, Cochemé HM, Khan S, Asghari S, Bhatia KP, Hardy J, Abramov AY, Partridge L.
Brain. 2015 Jul;138(Pt 7):1801-16. doi: 10.1093/brain/awv132. Epub 2015 May 22.
2013
[Molecular gerontology: towards healthy aging].
Castillo-Quan JI, Kinghorn KJ.
Gac Med Mex. 2013 Nov-Dec;149(6):680-5. Review. Spanish.
Kinghorn KJ, Kaliakatsos M, Blakely EL, Taylor RW, Rich P, Clarke A, Omer S.
J Neurol. 2013 Jan;260(1):3-9. doi: 10.1007/s00415-012-6564-9. Epub 2012 Jun 24. Review.
2011
Kinghorn KJ.
Dis Model Mech. 2011 Nov;4(6):713-5. doi: 10.1242/dmm.008615. Review.
Deriziotis P, André R, Smith DM, Goold R, Kinghorn KJ, Kristiansen M, Nathan JA, Rosenzweig R, Krutauz D, Glickman MH, Collinge J, Goldberg AL, Tabrizi SJ.
EMBO J. 2011 Jul 8;30(15):3065-77. doi: 10.1038/emboj.2011.224.
2006
Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer disease.
Kinghorn KJ, Crowther DC, Sharp LK, Nerelius C, Davis RL, Chang HT, Green C, Gubb DC, Johansson J, Lomas DA.
J Biol Chem. 2006 Sep 29;281(39):29268-77. Epub 2006 Jul 17.
Sharp LK, Mallya M, Kinghorn KJ, Wang Z, Crowther DC, Huntington JA, Belorgey D, Lomas DA.
FEBS J. 2006 Jun;273(11):2540-52.
2005
Molecular mousetraps and the serpinopathies.
Lomas DA, Belorgey D, Mallya M, Miranda E, Kinghorn KJ, Sharp LK, Phillips RL, Page R, Robertson AS, Crowther DC.
Biochem Soc Trans. 2005 Apr;33(Pt 2):321-30.
Crowther DC, Kinghorn KJ, Miranda E, Page R, Curry JA, Duthie FA, Gubb DC, Lomas DA.
Neuroscience. 2005;132(1):123-35.
2004
Polymerisation underlies alpha1-antitrypsin deficiency, dementia and other serpinopathies.
Lomas DA, Belorgey D, Mallya M, Onda M, Kinghorn KJ, Sharp LK, Phillips RL, Page R, Crowther DC, Miranda E.
Front Biosci. 2004 Sep 1;9:2873-91. Review.
Therapeutic targets from a Drosophila model of Alzheimer's disease.
Crowther DC, Kinghorn KJ, Page R, Lomas DA.
Curr Opin Pharmacol. 2004 Oct;4(5):513-6. Review.
Practical genetics: alpha-1-antitrypsin deficiency and the serpinopathies.
Crowther DC, Belorgey D, Miranda E, Kinghorn KJ, Sharp LK, Lomas DA.
Eur J Hum Genet. 2004 Mar;12(3):167-72. Review.