PUBLICATIONS | KinghornLab | London | Neuroscience

Selected only. A full publication list can be found by clicking here.

2021

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).

Klionsky, D.....Kinghorn KJ, et al.

Autophagy. 2021 Jan 17(1): 1-382. doi; 10.1080/15548627.2020.1797280

Finding genetically-supported drug targets for Parkinson's disease using Mendelian randomization of the druggable genome.

Storm C, et al.

Nature Communications. 2021 12(1): ARTN 7342. doi: 10.1038/s41467-021-26280-1.

2020

Fine-tuning autophagy maximises lifesoan and is associated with changes in mitochondrial gene expression in Drosophila.

Bjedov I, Cocheme HM, Foley A, Wiseler D, Woodling NS, castillo-Quan JI, Norvaisas P, Lujan C, Regan JC, Toivonen JM, Murphy MP, Thornton J, Kinghorn KJ, Neufeld TP, Cabreiro F, Partridge L.

PLoS Genet. 2020 Nov 30(11): e1009083. doi: 10.1371/journal.pgen.1009083.

Shifting equilibriums in Alzheimer's disease: the complex roles of microglia in neuroinflammation, neuronal survival and neurogenesis.

Gray SC, Kinghorn KJ, Woodling NS.

Neural Regen Res. 2020 Jan 15(7):1208-1219. doi: 10.4103/1673-5374.272571

2019

Agephagy-adapting autophagy for health during ageing.

Stead ER, Castillo-Quan JI, Miguel VEM, Kettler LC, Kinghorn KJ, Bjedov I.

Front Cell Dev Biol 2019 Nov 28: 7: 308. doi: 10.3389/fcell.2019.00308

A triple drug combination targeting components of the nutrient-sensing network maximizes longevity.

Castillo-Quan JI, Tain LS, Kinghorn KJ, Li L, Grönke S, Hinze Y, Blackwell TK, Bjedov I, Partridge L.

Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):20817-20819. doi: 10.1073/pnas.1913212116. Epub 2019 Sep 30.

2017

The emerging role of autophagic-lysosomal dysfunction in Gaucher disease and Parkinson's disease.

Kinghorn KJ, Asghari AM, Castillo-Quan JI.

Neural Regen Res. 2017 Mar;12(3):380-384. doi: 10.4103/1673-5374.202934

2016

A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin.

Kinghorn KJ, Grönke S, Castillo-Quan JI, Woodling NS, Li L, Sirka E, Gegg M, Mills K, Hardy J, Bjedov I, Partridge L.

J Neurosci. 2016 Nov 16;36(46):11654-11670.

Reply: Glial mitochondropathy in infantile neuroaxonal dystrophy: pathophysiological and therapeutic implications.

Kinghorn KJ, Castillo-Quan JI, Li L, Bhatia KP, Abramov AY, Hardy J, Partridge L.

Brain. 2016 Dec;139(Pt 12):e68. Epub 2016 Aug 6.

Mitochondrial dysfunction and defects in lipid homeostasis as therapeutic targets in neurodegeneration with brain iron accumulation.

Kinghorn KJ, Castillo-Quan JI.

Rare Dis. 2016 Jan 25;4(1):e1128616. doi: 10.1080/21675511.2015.1128616. eCollection 2016.

Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis.

Castillo-Quan JI, Li L, Kinghorn KJ, Ivanov DK, Tain LS, Slack C, Kerr F, Nespital T, Thornton J, Hardy J, Bjedov I, Partridge L.

Cell Rep. 2016 Apr 19;15(3):638-650. doi: 10.1016/j.celrep.2016.03.041. Epub 2016 Apr 7.

2015

Genetics and pharmacology of longevity: the road to therapeutics for healthy aging.

Castillo-Quan JI, Kinghorn KJ, Bjedov I.

Adv Genet. 2015;90:1-101. doi: 10.1016/bs.adgen.2015.06.002. Epub 2015 Jul 29. Review.

Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction.

Kinghorn KJ, Castillo-Quan JI, Bartolome F, Angelova PR, Li L, Pope S, Cochemé HM, Khan S, Asghari S, Bhatia KP, Hardy J, Abramov AY, Partridge L.

Brain. 2015 Jul;138(Pt 7):1801-16. doi: 10.1093/brain/awv132. Epub 2015 May 22.

2013

[Molecular gerontology: towards healthy aging].

Castillo-Quan JI, Kinghorn KJ.

Gac Med Mex. 2013 Nov-Dec;149(6):680-5. Review. Spanish.

Hypertrophic olivary degeneration on magnetic resonance imaging in mitochondrial syndromes associated with POLG and SURF1 mutations.

Kinghorn KJ, Kaliakatsos M, Blakely EL, Taylor RW, Rich P, Clarke A, Omer S.

J Neurol. 2013 Jan;260(1):3-9. doi: 10.1007/s00415-012-6564-9. Epub 2012 Jun 24. Review.

2011

Pathological looping in the synucleinopathies: investigating the link between Parkinson's disease and Gaucher disease.

Kinghorn KJ.

Dis Model Mech. 2011 Nov;4(6):713-5. doi: 10.1242/dmm.008615. Review.

Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry.

Deriziotis P, André R, Smith DM, Goold R, Kinghorn KJ, Kristiansen M, Nathan JA, Rosenzweig R, Krutauz D, Glickman MH, Collinge J, Goldberg AL, Tabrizi SJ.

EMBO J. 2011 Jul 8;30(15):3065-77. doi: 10.1038/emboj.2011.224.

2006

Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer disease.

Kinghorn KJ, Crowther DC, Sharp LK, Nerelius C, Davis RL, Chang HT, Green C, Gubb DC, Johansson J, Lomas DA.

J Biol Chem. 2006 Sep 29;281(39):29268-77. Epub 2006 Jul 17.

Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis.

Sharp LK, Mallya M, Kinghorn KJ, Wang Z, Crowther DC, Huntington JA, Belorgey D, Lomas DA.

FEBS J. 2006 Jun;273(11):2540-52.

2005

Molecular mousetraps and the serpinopathies.

Lomas DA, Belorgey D, Mallya M, Miranda E, Kinghorn KJ, Sharp LK, Phillips RL, Page R, Robertson AS, Crowther DC.

Biochem Soc Trans. 2005 Apr;33(Pt 2):321-30.

Intraneuronal Abeta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease.

Crowther DC, Kinghorn KJ, Miranda E, Page R, Curry JA, Duthie FA, Gubb DC, Lomas DA.

Neuroscience. 2005;132(1):123-35.

2004

Polymerisation underlies alpha1-antitrypsin deficiency, dementia and other serpinopathies.

Lomas DA, Belorgey D, Mallya M, Onda M, Kinghorn KJ, Sharp LK, Phillips RL, Page R, Crowther DC, Miranda E.

Front Biosci. 2004 Sep 1;9:2873-91. Review.

Therapeutic targets from a Drosophila model of Alzheimer's disease.

Crowther DC, Kinghorn KJ, Page R, Lomas DA.

Curr Opin Pharmacol. 2004 Oct;4(5):513-6. Review.

Practical genetics: alpha-1-antitrypsin deficiency and the serpinopathies.

Crowther DC, Belorgey D, Miranda E, Kinghorn KJ, Sharp LK, Lomas DA.

Eur J Hum Genet. 2004 Mar;12(3):167-72. Review.

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